Assessing the association between hypoxia during craniofacial development and oral clefts

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Rare Craniofacial Clefts

A general idea of the magnitude of the problem can be drawn from studies of the occurrence of the common clefts of the lip and palate (Davis (1935) found four median clefts of the lip and five oblique facial clefts in a series of 937 examples of common clefts of the lip and palate. Blackfield and Wilde (1950) noted only five lateral (transverse) facial clefts during a period in which they obser...

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Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor. Since the first report of an association between DNA sequence variants at the TGFA genetic locus and nonsyndromic oral clefts, 47 studies have been carried out, producing conflicting results. In this review, the author synthesizes findings from published reports on the association between the TGFA gene and ...

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ژورنال

عنوان ژورنال: Journal of Applied Oral Science

سال: 2018

ISSN: 1678-7765,1678-7757

DOI: 10.1590/1678-7757-2017-0234